SUBCELLULAR TECHNOLOGY LAB with GROUP OF ONCOENDOCRINOLOGY (SCT-lab)
Development of cancer is associated by complex interaction between malignant and normal cells. Understanding the mechanisms of this interaction determines the possibility of developing new methods of diagnosis and therapy. Our research is focused on circulating membrane nanovesicles, hormones and non-coding RNAs involved in regulation of tumour growth and metastatic progression. New analytical technologies are being developed to solve scientific problems and to be introduced into clinical practice as new methods of diagnostics and therapy.
Staff: doctor of science – 1, PhD – 4.
RESEARCH FIELDS:
ACHIEVEMENTS:
Development of new and optimization of existing methods for the isolation and analysis of circulating nanovesicles. Identification of vesicular markers of a number of oncological diseases (colorectal cancer, follicular thyroid cancer, Hodgkin's lymphoma).
Adaptation of the technology of two-tailed RT-qPCR for the analysis of short regulatory RNA molecules (miRNA). Development of a method for the isolation of specific microRNA molecules from plasma. Development of micro RNA panels for the diagnosis of a number of cancers (cervical and follicular thyroid cancer).
Investigation of hormonal and metabolic disorders associated with conservative therapy (chemo-, hormone-, immuno- and targeted therapy), and development of the approaches for their correction. Development of the so-called "three-weeks thyroglobulin test", during which the level of thyroglobulin is determined in the blood 3 weeks after extirpation of the thyroid gland.
HEAD OF THE LAB:
RESEACH STAFF:
“Onco-endocrinology” team
Berstein L.M., MD., prof.
Tsyrlina E.V., MD., PhD.
Vasiliev D.A., MD., PhD.
Kovalenko I.M., MD., PhD
“Nanovesicles-related technology” team
Nazarova I.V.
Nikiforova N.S.
Slyusarenko M.A.
“Methods of miRNA analysis” team:
Sidina E.I.
Knyazeva M.S.
Zabegina L.M.
Malysheva S.A.